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孙明斋

 

孙明斋 特任研究员

Email:mingzhai@ustc.edu.cn

主页:http://www.mbit.ustc.edu.cn

 

研究方向:

(1)基于单分子定位的光学超分辨显微镜。发展深度组织的三维超分辨成像技术以及其在生命科学研究中的应用;

(2)新型基于多光谱的生物医学成像技术;

(3)生物医疗图像信息学,开发新的图像分析算法以及基于

     机器学习的医学图像智能专家系统。

 

教育工作经历:

2012 – 2015 The Ohio State University,  Research Scientist

2008 – 2012  Princeton University,      博士后(生物物理)

2002 – 2008  University of Missouri,     博士 (生物物理)

1996 – 2001 中国科学技术大学,       学士  (化学物理)    

 

代表性论著:

(#:第一作者, *:通讯作者)

1. Huang, J., Gumpper, K., Chi, Y., Sun, M.#,*, & Ma, J. (2015). Fast two-dimensional super-resolution image reconstruction algorithm for ultra-high emitter density. Optics Letters, 40(13), 2989-2992.

2. Huang, J., Sun, M.#,*, Gumpper, K., Chi, Y., & Ma, J. (2015). 3D multifocus astigmatism and compressed sensing (3D MACS) based superresolution reconstruction. Biomedical optics express, 6(3), 902-917.

3. Smith, S. A., Sturm, A. C., Curran, J., Kline, C. F., Little, S. C., Bonilla, I. M., Sun, M. ... & Mohler, P. J. (2015). Dysfunction in the βII Spectrin–Dependent Cytoskeleton Underlies Human Arrhythmia. Circulation, 131(8), 695-708.

4. Qiu, J., He, D., Sun, M., Li, S., Wen, C., Hattrick-Simpers, J., ... & Cao, L. (2015). Effects of neutron and gamma radiation on lithium-ion batteries. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 345, 27-32.

5.  Lin, P. H., Duann, P., Komazaki, S., Park, K. H., Li, H., Sun, M., ... & Ma, J. (2015). Lysosomal two-pore channel subtype 2 (TPC2) regulates skeletal muscle autophagic signaling. Journal of Biological Chemistry, 290(6), 3377-3389.

6.  Sun, M.#,*,  Huang, J., Bunyak, F., Gumpper, K., De, G., Sermersheim, M., ... & Ma, J. (2014). Superresolution microscope image reconstruction by spatiotemporal object decomposition and association: application in resolving t-tubule structure in skeletal muscle. Optics express, 22(10), 12160-12176.

7. Balagam R, Litwin DB, Czerwinski F, Sun M, Kaplan HB, Shaevitz JW, et al. Myxococcus xanthus gliding motors are elastically coupled to the substrate as predicted by the focal adhesion model of gliding motility. Whitworth DE, editor. PLoS Comput Biol. 2014 May;10(5):e1003619.

8. Deng Y, Sun M, Lin P-H, Ma J, Shaevitz JW. Spatial covariance reconstructive (SCORE) super-resolution fluorescence microscopy. PLoS ONE. 2014;9(4):e94807.  

9. Deng Y, Coen P, Sun M, Shaevitz JW. Efficient multiple object tracking using mutually repulsive active membranes. PLoS ONE. 2013;8(6):e65769.

10. Nishi M, Aoyama F, Kisa F, Zhu H, Sun M, Lin P, et al. TRIM50 protein regulates vesicular trafficking for acid secretion in gastric parietal cells. J Biol Chem. 2012 Sep 28;287(40):33523–32.

11. Hong Z., Ersoy I., Sun M., Bunyak F., Hampel P. Jin M., and Palaniappan K. Influence of membrane cholesterol and substrate elasticity on endothelial cell spreading behavior. Journal of Biomedical Materials Research Part A, 2012:00A

12.  Levitan, I., Shentu, T. P., Sun, M., & Forgacs, G. (2015). The Role of Cholesterol and Lipoproteins in Control of Endothelial Biomechanics.Mechanobiology of the Endothelium, 146. (book chapter, )

13. Deng Y, Sun M, Shaevitz JW. Direct measurement of cell wall stress stiffening and turgor pressure in live bacterial cells. Phys Rev Lett. 2011 Oct 7;107(15):158101.

14. Sun M, Wartel M, Cascales E, Shaevitz JW, Mignot T. From the Cover: Motor-driven intracellular transport powers bacterial gliding motility. P Natl Acad Sci USA. 2011 May 3;108(18):7559–64.

15. Ersoy, I., Bunyak, F., Palaniappan, K., Sun, M., & Forgacs, G. (2008). Cell spreading analysis with directed edge profile-guided level set active contours. InMedical Image Computing and Computer-Assisted Intervention–MICCAI 2008(pp. 376-383).

16. Sun M, Northup N, Marga F, Huber T, Byfield FJ, Levitan I, et al. The effect of cellular cholesterol on membrane-cytoskeleton adhesion. J Cell Sci. 2007 ed. 2007 Jul 1;120(Pt 13):2223–31.

17. Hosu BG, Sun M, Marga F, Grandbois M, Forgacs G. Eukaryotic membrane tethers revisited using magnetic tweezers. Phys Biol. 2007 Jun;4(2):67–78.

18. Sun M, Graham JS, Hegedus B, Marga F, Zhang Y, Forgacs G, et al. Multiple membrane tethers probed by atomic force microscopy. Biophys J. 2005 ed. 2005 Dec; 89(6):4320–9.


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