Zachary J Smith 教授 博士生导师
办公电话： 63603760
个人主页：http://www.mbit.ustc.edu.cn/
个人简介：
Zachary Smith 十多年来一直从事生物光子方面的研究，已成功开发了基于手机的显微镜，光谱仪和粒度仪。集样品准备，测量和分析于一体的便携式自动化血检仪。在光谱技术方面首次提出了用局域光谱分析的概念实行化学监控,实现了在低信号的情况下确定并跟踪局域谱峰，将测量的精确率提高了十倍以上。同时开发了基于压缩传感(compressive sensing)的超快光谱仪，避免了将有限的光信号分布给众多像素，实现了快速高质量的光谱测量。
研究方向：
基于弹性散射光谱的便携式贫血诊断仪
基于手机的便携式农作物疾病诊断仪
开发可用于人和动物的便携式血检仪
用局域光谱分析方法来观察测量活细胞动态和细胞死亡的过程
利用压缩传感光谱仪进行细胞分类和超光谱成像。
学习经历：
1998.09-2002.05 University of Rochester，光学系，本科
2002.09-2009.05 University of Rochester，光学系，博士（导师：Andrew J Berger）
2009.10-2012.03 UC Davis，生物医学光子学研究中心，博士后（导师：Sebastian Wachsmann-Hogiu）
工作经历：
2012.04-2015.09 UC Davis，生物医学光子学研究中心，项目科学家(Assistant Project Scientist)
2015.09-至今中国科学技术大学精密机械与精密仪器系，教授
学术任职：
招生信息：
发表文章：
1、Wachsmann-Hogiu, S., Smith, Z. J., & Kahraman, M. (2019). Editorial: Plasmonic Technologies for Bioanalytical Applications. Frontiers in Chemistry, 7. doi:10.3389/fchem.2019.00865
2、Li, Y. N., Ma, X. G., Wang, W. H., Yan, S. J., Liu, F. S., Chu, K. Q., . . . Smith, Z. J. (2019). Improving the limit of detection in portable luminescent assay readers through smart optical design. Journal of Biophotonics. doi: 10.1002/jbio.201900241
3、Zhang, Y., Li, C. C., Hu, C. Z., Wu, Q., Cai, Y. P., Xing, S. G., . . . Zhang, H. F. (2019). Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP-1. EMBO Reports, 20(10). doi:DOI 10.15252/embr.201948115
4、Kheireddine, S., Smith, Z. J., Nicolau, D. V., & Wachsmann-Hogiu, S. (2019). Simple adaptive mobile phone screen illumination for dual phone differential phase contrast (DPDPC) microscopy. Biomedical Optics Express, 10(9), 4369-4380. doi:10.1364/Boe.10.004369
5、Ma, Y., Guo, S. Y., Pan, Y., Fan, R., Smith, Z. J., Lane, S., & Chu, K. Q. (2019). Quantitative phase microscopy with enhanced contrast and improved resolution through ultra-oblique illumination (UO-QPM). Journal of Biophotonics, 12(10). doi:10.1002/jbio.201900011
6、Li, Y. N., Zheng, R., Wu, Y. Z., Chu, K. Q., Xu, Q. M., Sun, M. Z., & Smith, Z. J. (2019). A low-cost, automated parasite diagnostic system via a portable, robotic microscope and deep learning. Journal of Biophotonics, 12(9). doi:10.1002/jbio.201800410
7、Xiao, C., Smith, Z. J., & Chu, K. (2019). Simultaneous recovery of both bright and dim structures from noisy fluorescence microscopy images using a modified TV constraint. Journal of Microscopy, 275(1), 24-35. doi:10.1111/jmi.12799
8、Li, X. Y., Deng, Q., Liu, H. P., Lei, Y. W., Fan, P. W., Wang, B., . . . Gao, T. J. (2019). A smart preparation strategy for point-of-care cellular counting of trace volumes of human blood. Analytical and Bioanalytical Chemistry, 411(13), 2767-2780. doi:10.1007/s00216-019-01738-w
9、Liu, G. H., Dong, F. F., Fu, C. H., & Smith, Z. J. (2019). Automated morphometry toolbox for analysis of microscopic model organisms using simple bright-field imaging. Biology Open, 8(3). doi:10.1242/bio.037788
10、Kheireddine, S., Perumal, A. S., Smith, Z. J., Nicolau, D. V., & Wachsmann-Hogiu, S. (2019). Dual-phone illumination-imaging system for high resolution and large field of view multi-modal microscopy. Lab on a Chip, 19(5), 825-836. doi:10.1039/c8lc00995c
11、Tong, L. S., Kauer, J., Chen, X., Chu, K. Q., Dou, H., & Smith, Z. J. (2018). Screening of nutritional and genetic anemias using elastic light scattering. Lab on a Chip, 18(21). doi:10.1039/c8lc00377g
12、Van Cleuvenbergen, S., Smith, Z. J., Deschaume, O., Bartic, C., Wachsmann-Hogiu, S., Verbiest, T., & van der Veen, M. A. (2018). Morphology and structure of ZIF-8 during crystallisation measured by dynamic angle-resolved second harmonic scattering. Nature Communications, 9. doi:10.1038/s41467-018-05713-4
13、Lu, Q., Liu, G. H., Xiao, C. L., Hu, C. Z., Zhang, S. W., Xu, R. X., . . . Smith, Z. J. (2018). A modular, open-source, slide-scanning microscope for diagnostic applications in resource-constrained settings. Plos One, 13(3). doi:10.1371/journal.pone.0194063
14、Ye, J., Liu, G. H., Liu, P., Zhang, S. W., Shao, P. F., Smith, Z. J., . . . Xu, R. X. (2018). Benchtop and animal validation of a portable fluorescence microscopic imaging system for potential use in cholecystectomy. Journal of Biomedical Optics, 23(2). doi:10.1117/1.Jbo.23.2.020504
15、Cai, B., Zhai, X. M., Wang, Z. G., Shen, Y., Xu, R., Smith, Z. J., . . . Chu, K. Q. (2018). Optical volumetric projection for fast 3D imaging through circularly symmetric pupil engineering. Biomedical Optics Express, 9(2), 437-446. doi:10.1364/Boe.9.000437
16、Ma, Y., Li, D., Smith, Z. J., Li, D., & Chu, K. Q. (2018). Structured illumination microscopy with interleaved reconstruction (SIMILR). Journal of Biophotonics, 11(2). doi:10.1002/jbio.201700090
17、Xie, D. L., Xie, Y. J., Liu, P., Tong, L. S., Hu, C. Z., Shao, P. F., . . . Smith, Z. J. (2018). Performance of a cost-effective and automated blood counting system for resource-limited settings operated by trained and untrained users. Journal of Biophotonics, 11(2). doi:10.1002/jbio.201700030
18、Tong, L., Kauer, J., Wachsmann-Hogiu, S., Chu, K. Q., Dou, H., & Smith, Z. J. (2017). A new red cell index and portable RBC analyzer for screening of iron deficiency and Thalassemia minor in a Chinese population. Scientific Reports, 7. doi:10.1038/s41598-017-11144-w
19、de Menezes, R. F., Harvey, C. M., Gerbi, M. E. M. D., Smith, Z. J., Smith, D., Ivaldi, J. C., . . . Wachsmann-Hogiu, S. (2017). Fs-laser ablation of teeth is temperature limited and provides information about the ablated components. Journal of Biophotonics, 10(10), 1292-1304. doi:10.1002/jbio.201700042
20、Jiang, S., Zhang, X. B., Zhang, Y., Hu, C. R., Zhang, R., Zhang, Y., . . . Hou, J. G. (2017). Subnanometer-resolved chemical imaging via multivariate analysis of tip-enhanced Raman maps. Light-Science & Applications, 6. doi:10.1038/lsa.2017.98
21、Carney, R. P., Hazari, S., Colquhoun, M., Di, T., Hwang, B., Mulligan, M. S., . . . Lam, K. S. (2017). Multispectral Optical Tweezers for Biochemical Fingerprinting of CD9-Positive Exosome Subpopulations. Analytical Chemistry, 89(10), 5357-5363. doi:10.1021/acs.analchem.7b00017
22、Das, N. K., Dai, Y. C., Liu, P., Hu, C. Z., Tong, L. S., Chen, X. Y., & Smith, Z. J. (2017). Raman Plus X: Biomedical Applications of Multimodal Raman Spectroscopy. Sensors, 17(7). doi:10.3390/s17071592
23、Buzas, E. I., Gardiner, C., Lee, C., & Smith, Z. J. (2017). Single particle analysis: Methods for detection of platelet extracellular vesicles in suspension (excluding flow cytometry). Platelets, 28(3), 249-255. doi:10.1080/09537104.2016.1260704
24、Smith, Z. J., Lee, C., Rojalin, T., Wachsmann-Hogiu, S. (2016), Comment on “Label-Free Single Exosome Detection Using Frequency Locked Microtoroid Optical Resonators, ACS Photonics, 3(4), 716-717. doi:10.1021/acsphotonics.5b00722
25、Gill, R. K., Smith, Z. J., Lee, C. W., & Wachsmann-Hogiu, S. (2016). The effects of laser repetition rate on femtosecond laser ablation of dry bone: a thermal and LIBS study. Journal of Biophotonics, 9(1-2), 171-180. doi:10.1002/jbio.201500144
26、Smith, Z.J., Lee, C., Rojalin, T., Carney, R.P., Hazari, S., Knudson, A.,. . ., Wachsmann-Hogiu, S. (2015), Single exosome study reveals subpopulations distributed among cell lines with variability related to membrane content, Journal of Extracellular Vesicles, 4(1), 28533. doi:10.3402/jev.v4.28533
27、Chu, K. Q., Smith, Z. J., & Wachsmann-Hogiu, S. (2015). Development of inexpensive blood imaging systems: where are we now? Expert Review of Medical Devices, 12(5), 613-627. doi:10.1586/17434440.2015.1075388
28、Gao, T. J., Smith, Z. J., Lin, T. Y., Holt, D. C., Lane, S. M., Matthews, D. L., . . . Wachsmann-Hogiu, S. (2015). Smart and Fast Blood Counting of Trace Volumes of Body Fluids from Various Mammalian Species Using a Compact, Custom-Built Microscope Cytometer. Analytical Chemistry, 87(23), 11854-11862. doi:10.1021/acs.analchem.5b03384
29、Gill, R. K., Smith, Z. J., Panchal, R. R., Bishop, J. W., Gandour-Edwards, R., & Wachsmann-Hogiu, S. (2015). Preliminary fsLIBS study on bone tumors. Biomedical Optics Express, 6(12), 4850-4858. doi:10.1364/Boe.6.004850
30、Lee, C., Carney, R. P., Hazari, S., Smith, Z. J., Knudson, A., Robertson, C. S., . . . Wachsmann-Hogiu, S. (2015). 3D plasmonic nanobowl platform for the study of exosomes in solution. Nanoscale, 7(20), 9290-9297. doi:10.1039/c5nr01333j
承担科研项目：
1、外泌体单体的精准检测和多模态表征技术，国家自然科学基金委，主特 2018.01-2021.12
2、无标识纳米化学发光原理性检测器件与试剂盒的研制，国家科技部，参与 2016.07-2021.06
专利情况：
1、一种全自动化的肠道寄生虫虫卵诊断成像系统 ZL201820749650.X
2、便携式血细胞计数监测器 CN105228749B
3、Portable Blood Count Monitor （美国专利）US10024858B2