徐晓嵘

徐晓嵘教授，博士生导师

办公电话：

邮箱：xux@ustc.edu.cn

个人简介：

徐晓嵘博士为中国科学技术大学教授，博士生导师，英国物理学会(Institute of Physics)会士、国际光电工程学会(SPIE)资深会员。1992年本科毕业于中国科学技术大学精密机械与仪器系；1995年硕士毕业于美国纽约州立大学石溪分校；1999年博士毕业于美国麻省理工学院机械工程系；之后在斯坦福大学设计研究中心从事博士后研究； 2000年加盟美国硅谷一家医疗仪器初创公司任技术总监；2004年底被聘为俄亥俄州立大学生物医学工程系助理教授，后晋升为副教授（终身教职）; 2012年回中国科学技术大学服务; 2014年至2018年任精密机械与精密仪器系系主任; 2021年加盟中国科学技术大学苏州高等研究院。徐教授的研究方向包括生物医学光学与手术导航、微纳米药物包裹以及生物医学仿生仿体的三维打印，已承担了国内外研究项目二十多项，在高影响力SCI期刊上发表了一百多篇学术论文。他的研究被《Columbus CEO》杂志专题报道，被评为年度十大最优秀的俄亥俄人物及两大科研明星（唯一的获奖华人）, 获得了Wallace H. Coulter转化医学青年成就奖，俄亥俄州年度TechColumbus 发明家奖以及 “Lumbley Research Award”等学术奖项。

研究方向：

多模态医疗影像及手术导航：带领团队研制了十余款便携式诊疗及手术导航系统，实现了两项技术的产业转化和临床应用，申请了20余项国内和国际专利。首次提出原位投射式手术导航和远程手术技术，使得医生仅靠裸眼即可精准观测到病灶边界及手术路径，大大提升了手术效果，相关技术已在数百例临床实验中得到了验证。基于深度学习的皮肤镜自动诊疗技术在国际皮肤病诊断竞赛中取得佳绩，有助于缓解边远地区医疗资源缺乏的状况，提升人民健康水平。
微纳米药物包裹：采用流动聚焦、电雾化以及界面剪切等微流控技术构建了具有多层复杂结构和多组分的微纳胶囊，实现了氧、纳米颗粒、药物和细胞的高通量均一包裹，采用磁场、光学、超声及温度等外界主动激励实现了载药可激发微囊的定向富集和遥控释放，并且拓展了微液滴技术在多个领域的应用，相关研究成果在Nature, Biomaterials, Lab on a Chip，Advanced Science, ACS Applied Materials and Interfaces 等专业期刊发表。
医疗仪器标准化：针对医学光学仪器缺乏可溯源标准的现状，开拓了可溯源标准仿生仿体的研究，首次提出数字仿体的概念并制备了能够模拟红细胞氧合和光谱特性的微球，承担了国家基金委重大科学仪器研制项目并成功研制了仿生生物光学仿体的三维打印系统。

重要科研获奖情况：

Wallace Coulter 转化医学青年成就奖（2007）

俄亥俄十大杰出人物，当年唯一获奖华人（2010）

俄亥俄州TechColumbus发明家奖，当年唯一获奖人（2011）

英国物理学会（Institute of Physics）会士（2015）

近5年内公开发表学术论文和公开出版的著作：

2021年：

·S. Ali, F. Mangrio, F. Li, P. Dwivedi, M. Rajput, R. Ali, M. Khan, W. Ding, R.X. Xu*, “Co-delivery of artemether and piperine via core-shell microparticles for enhanced sustained release”, Journal of Drug Delivery Science and Technology, 63, 102505 (2021). IF: 2.734

·S. Wang, Z. Zhu, C. Ma, R. Qiao, C. Yang, R.X. Xu, T. Si, “Generation of non-spherical liquid metal microparticles with tunable shapes exhibiting electrostatic- responsive performance”. ACS Applied Materials & Interfaces , 13 (14): 16677-16687 (2021). IF: 8.758

·M. Zhang, S. Wang, Y. Zhu, Z. Zhu, T. Si, R.X. Xu*, “Programmable dynamic interfacial spinning of bioinspired microfibers with volumetric encoding”, Materials Horizons， 8， 1756-1768 (2021). IF: 12.31

·R. Zhang, R. Yang, Z. Lang, B. Wu, P. Shao, P. Liu, X. Zhong, C. Contreras, R.X. Xu*, “Coaxial projective imaging for sentinel lymph node mapping in melanoma: a case report”, JAAD Case Reports, (2021,accepted). IF: 1.104

·Y. Qu, Z. Smith, J. Smith, K. Tyler, S. Chang, S. Shen, M. Sun, R. X. Xu*, “Applying limiting entropy to quantify the alignment of collagen fibers by polarized light imaging”, Mathematical Biosciences and Engineering 18(3), 2331-2356 (2021). IF: 1.338

2020年：

·Y. Xue, L. Qi, Y. Niu, H. Huang, F. Huang, T. Si*, Y. Zhao*, and R. X. Xu*, Integration of Electrospray and Digital Light Processing for Freeform Patterning of Porous Microstructures, Advanced Materials Technologies 2000578 (2020). IF: 5.969

·C. Sun, H. You*, Y. Xie, and R. X. Xu, Performance Optimization of Microvalves Based on a Microhole Array for Microfluidic Chips, J Anal Methods Chem 2020(8842890-8842890 (2020). IF: 1.878

·P. Liu, C. Li, C. Xiao, Z. Zhang, J. Ma, J. Gao, P. Shao, I. Valerio, T. Pawlik, C. Ding, A. Yilmaz, and R. X. Xu*, A wearable augmented reality navigation system for surgical telementoring based on Microsoft HoloLens, Annals of Biomedical Engineering 49, 287-298, DOI: 10.1007/s10439-020-02538-5 (2020). IF: 3.474

·P. Dwivedi, S. Kiran, S. Han, M. Dwivedi, R. Khatik, R. Fan, F. A. Mangrio, K. Du, Z. Zhu, and C. Yang, F. Huang, A. Ejaz, R. Han, T. Si, R.X. Xu*, Magnetic targeting and ultrasound activation of liposome-microbubble conjugate for enhanced delivery of anti-cancer therapies, ACS applied materials & interfaces 12(21), 23737-23751 (2020). IF: 8.456

·Y. Qu, Y. Meng, S. Feng, M. Liu, L. Xiao, X. Zhang, S. Chang, and R. Xu*, Therapeutic Assessment of High-intensity Focused Ultrasound for Vulvar Lichen Sclerosus by Active Dynamic Thermal Imaging and Hyperspectral Imaging—A Preliminary Study, Frontiers in Physics 8(91) (2020). IF: 1.895

·F. Huang, Z. Zhu, Y. Niu, Y. Zhao, T. Si*, and R. X. Xu*, Coaxial oblique interface shearing: tunable generation and sorting of double emulsions for spatial gradient drug release, Lab on a Chip 20(7), 1249-1258 (2020). IF: 6.914

·W. Xu, H. Zheng, Y. Liu, X. Zhou, C. Zhang, Y. Song, X. Deng, M. Leung, Z. Yang, R. X. Xu, Z. L. Wang, X. C. Zeng and Z. Wang, A droplet-based electricity generator with high instantaneous power density, Nature (2020). IF: 43.070

2019年：

·C. Ma, S. Shen, G. Liu, S. Guo, B. Guo, J. Li, K. Huang, Y. Zheng, P. Shao, E. Dong, J. Chu and R. X. Xu, Multimodal 3D Printing of Phantoms to Simulate Biological Tissue, J Vis Exp 155), (2020). IF: 1.325

·S. Kiran, P. Dwivedi, R. Khatik, S. Hameed, M. Dwivedi, F. Huang and R. X. Xu*, Synthesis of a functionalized dipeptide for targeted delivery and pH-sensitive release of chemotherapeutics, Chem Commun (Camb) 56(2), 285-288 (2019). IF: 6.164

·F. Huang, Y. Niu, Z. Zhu, H. Huang, Y. Xue, T. Si, R. X. Xu* and Y. Zhao*, Oblique interface shearing (OIS): single-step microdroplet generation and on-demand positioning, Soft Matter 15(24), 4782-4786 (2019). IF: 3.399

·S. Liu, H. Wang, C. Zhang, J. Dong, S. Liu, R. Xu and C. Tian, In Vivo Photoacoustic Sentinel Lymph Node Imaging Using Clinically-Approved Carbon Nanoparticles, IEEE Trans Biomed Eng (2019). IF: 4.491

·F. Zhang, X. Zhu, J. Gao, B. Wu, P. Liu, P. Shao, M. Xu, T. M. Pawlik, E. W. Martin and R. X. Xu, Coaxial projective imaging system for surgical navigation and telementoring, J Biomed Opt 24(10), 1-9 (2019). IF: 3.337

·C. Li, P. Liu, P. Shao, J. Pei, Y. Li, T. M. Pawlik, E. W. Martin and R. X. Xu, Handheld projective imaging device for near-infrared fluorescence imaging and intraoperative guidance of sentinel lymph node resection, J Biomed Opt 24(8), 1-4 (2019). IF: 2.367

·G. Tang, R. Xiong, D. Lv, R. X. Xu, K. Braeckmans, C. Huang and S. C. De Smedt, Gas‐Shearing Fabrication of Multicompartmental Microspheres: A One‐Step and Oil‐Free Approach, Advanced Science 1802342 (2019). IF: 15.804

·M. Zhang, Z. Zhu, S. Yuan, S. Wang, C. Yang, P. Dwivedi, T. Si and R. X. Xu*, One-step microencapsulation and spraying of pesticide formulations for improved adhesion and sustained release, Journal of Microencapsulation 36(7), 649-658 (2019). IF: 1.585

·W. Xu, X. Zhou, C. Hao, H. Zheng, Y. Liu, X. Yan, Z. Yang, M. Leung, X. C. Zeng, R. X. Xu and Z. Wang, SLIPS-TENG: robust triboelectric nanogenerator with optical and charge transparency using a slippery interface, National Science Review 6(3), 540-550 (2019). IF: 13.833

·C. Yang, R. Qiao, K. Mu, Z. Zhu, R. X. Xu and T. Si, Manipulation of jet breakup length and droplet size in axisymmetric flow focusing upon actuation, Physics of Fluids 31(9), 091702 (2019). IF: 2.840

·Z. Zhu, F. Huang, C. Yang, T. Si and R. X. Xu, On-Demand Generation of Double Emulsions Based on Interface Shearing for Controlled Ultrasound Activation, ACS applied materials & interfaces 11(43), 40932-40943 (2019). IF: 8.456

·S. Han, P. Dwivedi, F. Mangrio, M. Dwivedi, R. Khatik, D. Cohn, T. Si and R. Xu*, Sustained Release Paclitaxel Loaded Core-Shell Structured Solid Lipid Microparticles for Intraperitoneal Chemotherapy of Ovarian Cancer, Artificial Cells, Nanomedicine and Biotechnology (2019 , in press). IF: 3.026

·S. Shen, H. Wang, Y. Qu, K. Huang, G. Liu, Z. Chen, C. Ma, P. Shao, J. Hong, P. Lemaillet, E. Dong and R. X. Xu*, Simulating orientation and polarization characteristics of dense fibrous tissue by electrostatic spinning of polymeric fibers, Biomedical optics express 10(2), 571-583 (2019). IF: 3.337

·P. Dwivedi, S. Han, F. Mangrio, R. Fan, M. Dwivedi, Z. Zhu, F. Huang, Q. Wu, R. Khatik, D. E. Cohn, T. Si, S. Hu, A. Sparreboom and R. X. Xu, Engineered multifunctional biodegradable hybrid microparticles for paclitaxel delivery in cancer therapy, Materials Science & Engineering C 102(113-123 (2019). IF: 5.08

2018年：

·Z. Zhu, Q. Wu, S. Han, W. Xu, F. Zhong, S. Yuan, P. Dwivedi, T. Si and R. X. Xu*, Rapid production of single-and multi-compartment polymeric microcapsules in a facile 3D microfluidic process for magnetic separation and synergistic delivery, Sensors and Actuators B: Chemical 275(190-198 (2018). IF: 5.667

·J. Ye, G. Liu, P. Liu, S. Zhang, P. Shao, Z. J. Smith, C. Liu and R. X. Xu*, Benchtop and animal validation of a portable fluorescence microscopic imaging system for potential use in cholecystectomy, J Biomed Opt 23(2), 1-4 (2018). IF: 2.859

·Q. Wu, C. Yang, J. Yang, F. Huang, G. Liu, Z. Zhu, T. Si and R. X. Xu*, Photopolymerization of complex emulsions with irregular shapes fabricated by multiplex coaxial flow focusing, Applied Physics Letters 112(7), 071601 (2018). IF: 3.495

·X. Lv, H. Chen, G. Liu, S. Shen, Q. Wu, C. Hu, J. Li, E. Dong and R. X. Xu*, Design of a portable phantom device to simulate tissue oxygenation and blood perfusion, Appl Opt 57(14), 3938-3946 (2018). IF: 1.791

·Q. Lu, G. Liu, C. Xiao, C. Hu, S. Zhang, R. X. Xu, K. Chu, Q. Xu and Z. J. Smith, A modular, open-source, slide-scanning microscope for diagnostic applications in resource-constrained settings, PLoS One 13(3), e0194063 (2018). IF: 2.766

·G. Liu, Q. Wu, P. Dwivedi, C. Hu, Z. Zhu, S. Shen, J. Chu, G. Zhao, T. Si and R. X. Xu*, Hemoglobin-Laden Microcapsules for Simulating Oxygen Dynamics of Biological Tissue, ACS Biomaterials Science & Engineering 4(9), 3177-3184 (2018). IF: 4.432

·G. Liu, K. Huang, Q. Jia, S. Liu, S. Shen, J. Li, E. Dong, P. Lemaillet, D. W. Allen and R. X. Xu*, Fabrication of a multilayer tissue-mimicking phantom with tunable optical properties to simulate vascular oxygenation and perfusion for optical imaging technology, Appl Opt 57(23), 6772-6780 (2018). IF: 1.791

·Z. Deng, S. Yuan, R. X. Xu, H. Liang and S. Liu, Reduction-Triggered Transformation of Disulfide-Containing Micelles at Chemically Tunable Rates, Angew Chem Int Ed Engl 57(29), 8896-8900 (2018). IF: 12.102

·B. Cai, X. Zhai, Z. Wang, Y. Shen, R. Xu, Z. J. Smith, Q. Wen and K. Chu, Optical volumetric projection for fast 3D imaging through circularly symmetric pupil engineering, Biomedical optics express 9(2), 437-446 (2018). IF: 3.337

·K. Mu, T. Si, E. Li, R. X. Xu and H. Ding, Numerical study on droplet generation in axisymmetric flow focusing upon actuation, Physics of fluids 30(012111 (2018). IF: 2.279

·R. Zheng, L. Liu, S. Zhang, C. Zheng, F. Bunyak, R. Xu, B. Li and M. Sun, Detection of exudates in fundus photographs with imbalanced learning using conditional generative adversarial network, Biomedical optics express 9(10), 4863-4878 (2018). IF: 3.337

·X. Li, J. Xie, S. Tang, R. Xu, X. Li, W. Li and S. Zhang, A Controllable Untethered Vehicle Driven by Electrically Actuated Liquid Metal Droplets, IEEE Transactions on Industrial Informatics 1-1 (2018). IF: 6.764

2017年：

·Q. Wu, C. Yang, G. Liu, W. Xu, Z. Zhu, T. Si and R. X. Xu*, Multiplex coaxial flow focusing for producing multicompartment Janus microcapsules with tunable material compositions and structural characteristics, Lab Chip, DOI: 10.1039/c7lc00769h (2017). IF: 6

·J. Xu, S. Yuan, J. Tian, K. A. Martin, J. Song, C. Li, Z. Wang, J. Lin, T. Si and R. X. Xu*, Ultrasound mediated delivery of oxygen and LLL12 loaded stimuli responsive microdroplets for the treatment of hypoxic cancer cells, Scientific reports 7(44908 (2017). IF: 4.122

·S. Shen, H. Wang, L. Yuan, X. Zhou, X. Du, Z. Zhao, E. Dong, B. Liu, W. Liu, B. Cromeens4, B. Adler, G. Besner, R. X. Xu*, Freeform fabrication of a tissue-simulating phantom for surgical planning in conjoined twin separation surgery, Scientific Reports 7(1), 11048 (2017). IF: 4.122

·F. A. Mangrio, P. Dwivedi, S. Han, G. Zhao, D. Gao, T. Si and R. X. Xu*, Characteristics of Artemether-Loaded Poly(lactic-co-glycolic) Acid Microparticles Fabricated by Coaxial Electrospray: Validation of Enhanced Encapsulation Efficiency and Bioavailability, Mol Pharm 14(12), 4725-4733 (2017). IF: 4.556

·W. Ren, Y. Qu, J. Pei, L. Xiao, S. Zhang, S. Chang and R. X. Xu*, Development of a Multimodal Colposcopy for Characterization of Cervical Intraepithelial Neoplasia, Journal of Medical Devices 11(3), 031005-031005-031010 (2017) . IF: 0.412

·R. Ma, Q. Wu, T. Si, S. Chang and R. X. Xu*, Oxygen and Indocyanine Green loaded microparticles for dual-mode imaging and sonodynamic treatment of cancer cells, Ultrasonics sonochemistry 39, p197-207 (2017). IF: 6.012

·J. Tian, H. Xiao, R. Wu, Y. Cao, C. Li, R. Xu, C. R. Pierson, J. L. Finlay, F. Yang, N. Gu and J. Lin*, The Antiproliferative and Colony-suppressive Activities of STAT3 Inhibitors in Human Cancer Cells Is Compromised Under Hypoxic Conditions, Anticancer Res 37(2), 547-553 (2017). IF: 1.937

·Y. Niu, X. Zhang, T. Si, Y. Zhang, L. Qi, G. Zhao, R. X. Xu*, X. He and Y. Zhao, Simultaneous Measurements of Geometric and Viscoelastic Properties of Hydrogel Microbeads Using Continuous-Flow Microfluidics with Embedded Electrodes, Small 13(48), (2017). IF: 9.598

2016年：

·Z. Zhu, Q. Wu, G. Li, S. Han, T. Si and R. X. Xu*, Microfluidic fabrication of stimuli-responsive mi-crodroplets for acoustic and optical droplet vaporizations, Journal of Materials Chemistry B DOI: 10.1039/C1035TB02402A (2016). IF: 4.776

·Q. Gan, D. Wang, J. Ye, Z. Zhang, X. Wang, C. Hu, P. Shao and R. X. Xu*, Benchtop and Animal Validation of a Projective Imaging System for Potential Use in Intraoperative Surgical Guidance, PLoS One 11(7), e0157794 (2016). IF: 2.766

·Z. Zhang, J. Pei, D. Wang, Q. Gan, J. Ye, J. Yue, B. Wang, S. P. Povoski, E. W. Martin, Jr., C. L. Hitchcock, A. Yilmaz, M. F. Tweedle, P. Shao and R. X. Xu*, A Wearable Goggle Navigation System for Dual-Mode Optical and Ultrasound Localization of Suspicious Lesions: Validation Studies Using Tissue-Simulating Phantoms and an Ex Vivo Human Breast Tissue Model, PLoS One 11(7), e0157854 (2016). IF: 2.766

·P. Liu, J. Huang, S. Zhang and R. X. Xu*, Multiview hyperspectral topography of tissue structural and functional characteristics, J Biomed Opt 21(1), 16012 (2016). IF: 2.367

·T. Si, G. Li, Q. Wu, Z. Zhu, X. Luo and R. X. Xu*, Optical droplet vaporization of nanoparticle-loaded stimuli-responsive microbubbles, Applied Physics Letters 108(11), 111109 (2016). IF: 3.495

·T. Si, C. Yin, P. Gao, G. Li, H. Ding, X. He, B. Xie and R. X. Xu*, Steady cone-jet mode in compound-fluidic electro-flow focusing for fabricating multicompartment microcapsules, Applied Physics Letters 108), 021601 (2016). IF: 3.495

·J. Sun, M. Yin, S. Zhu, L. Liu, Y. Zhu, Z. Wang, R. X. Xu and S. Chang, Ultrasound-mediated destruction of oxygen and paclitaxel loaded lipid microbubbles for combination therapy in hypoxic ovarian cancer cells, Ultrasonics sonochemistry 28, p319-326 (2016)

·S. Chang, T. Si, S. Zhang, M. A. Merrick, D. E. Cohn and R. X. Xu*, Ultrasound mediated destruction of multifunctional microbubbles for image guided delivery of oxygen and drugs, Ultrasonics Sonochemistry 28, p31-38 (2016)